Research programs

These flagship programs focus on bringing together reseachers from across the University to solve some of the world's largest challenges that are of a social, economic and scientific significance. The six Grand Challenge projects are: 

•  Advanced Capture of Water from the Atmosphere (ACWA) 
• CO2 Zero
• Safe-by-Design Nanotechnology 
• Nanorobotics for Health
• Computational Materials Discovery 
• Unlocking the Neural Interface

The Frontier scheme is designed to assess and develop one emerging technology platform in multiple applications to identify technology transfer opportunities over a diverse range of sectors.

Quantum Sensing

Chief investigator: James Rabeau

Quantum technologies have reached an inflection point in terms of technological maturity and are one step closer to being used in real world applications. Quantum sensing effectively takes advantage of the inherent weakness of all quantum systems: their sensitivity to the external environment. This project will undertake a detailed survey of the application landscape for quantum sensing, and in particular, will provide opportunities to collaborate or partner with industry/research to develop focused quantum sensing devices for real-world problems.  

The Catalyst scheme underpins Grand Challenges or encourage new ways of thinking about research. It aims to bring together researchers from Social Sciences, Design, Law and the Business School with scientist from Science, Health Sciences, Medicine and Engineering.

Engaged Innovation Scholarship for Impact

Chief Investigators: Steven Maguire, Eric Knight

This transversal program aims to bring innovation, entrepreneurship, design thinking and sustainability to each of the Grand Challenge projects. This includes integrative cross-cutting research from The University of Sydney Business School and is for anyone interested in studying the innovation and commercialisation of nanoscience technologies ‘in the making’ by offering the opportunity to be engaged in a multidisciplinary team.

NanoResonance

Chief Investigator: Diana Chester

This Catalyst project will use data collected from a research initiative at Sydney Nano to develop a creative arts project using virtual reality and spacialied audio. The key objectives of the project are, 1) to bring better visibility to collaborative possibilities between Sydney Nano and the Faculty of Arts and Social Sciences; 2) to use visual and sonic data visualisation capabilities to make sense of data generated in a nano environment and to share it with an audience; and 3) to increase the impact of Sydney Nano research by making it visible to a broader audience through creative outputs.

Nanosonic Stories

Chief Investigator: Alice Motion

This catalyst project will research effective ways to communicate nanoscience through sound. Using original compositions of music, soundscapes and aural storytelling, this project aims to both find new ways to audibly illustrate scientific concepts and articulate emotions inspired by science at some of the smallest scales. Alice and her collaborators will explore the ability of music and sound to reach new audiences and connect people with science and develop a program of expertise in audio science communication to inform and contribute to science podcasts and immersive experiences that will also make science communication more inclusive.

The Kickstarter projects are precursors for Grand Challenges and must comprise of a multi-disciplinary team with researchers from across at least two Faculties, with humanitarian or environmental impact.

NanoVision

Chief Investigators: Mark Gillies, Wojciech Chrzanowski, Ling Zhu

This project aims to transform treatment of blindness by harnessing the combined advances in nanomedicine engineering and synthetic biology to manipulate the genetic code that enables the blind to see. Through nanotechnology, we can revolutionise the delivery of drugs to treat retinal diseases such as age-related macular degeneration (AMD) and diabetic retinopathy (DR), which are leading causes of blindness.

Organs-on-chips: Tissues-in-fibres

Chief Investigator: Stuart Fraser, Marcela Bilek

The modelling of biological processes is moving away from animal experimentation due to ethical and species-dependent concerns. The field of "organs-on-chips" or engineered, stem cell-derived complex cellular interactions grown in vitro is expanding rapidly. The team assembled has the ability to generate highly specific engineered biofunctionalised 2-D and 3-D surfaces to combine with stem cell differentiation to form mature functional tissue-like structures in the dish as well as tissue-like structures in biofunctionalised fibres. This project aims to focus these efforts to generate experimentally and potentially therapeutically useful biological structures in a highly engineered, reproducible manner.

GeneNano

Chief Investigator: Robyn Jamieson

This project aims to provide new approaches in therapies for genetic retinal disorders using novel carbon nanoparticle carriers. Novel carbon nanoparticles offer a promising solution for gene therapy and other genetic modification clinical trials. The carbon-based nanoparticles created in plasma have tuneable size, shape, charge, surface chemistry and scalable cost-effective production. They covalently immobilise functional macromolecules on contact and readily enter multiple cell types, with no toxicity, effectively carrying siRNA, plasmid DNA cargo and antibodies to cells of interest.

NanoCardio

Chief Investigators: David Martinez Martin, Corinne Caillaud

High blood pressure (BP) is a major leading risk factor for disability, cardiovascular disease and kidney chronic disease, which is linked to 1 in 5 of all deaths. The lack of suitable technologies to reliably track and communicate BP to patients contributes to have a large number of undiagnosed cases which prevents such patients from receiving existing effective treatments and better lifestyle recommendations. The goal of the project is to develop the scientific and technological grounds to accurately and non-invasively track the BP of patients in real-time and over a period of hours to days. To do that, two different strategies will be pursued: Heart Sound and Continuous Unobtrusive Monitoring of BP with ultrasensitive optical fibres.

• DNA origami robots - Ali Abbas, Shelley Wickham
• Developing analysis methodologies for atom probe microscopy - Anna Ceguerra
• Engineered quantum molecular systems - Ivan Kassal
• Extracellular vesicles - Georges Grau
• Hybrid plasmonic waveguide for on-chip photonic devices - Stefano Palomba, Alessandro Tuniz, Martijn de Sterke
• Inhaled phage therapy - Hak-kim Chan, Yoon Kyung Chang
• Integrated microwave photonics - Xiaoke Yi
• Linking fundamental to applied photonics - Benjamin Eggleton
• Measurement and control at the nanoscale - David Reilly
• Molecular simulation of polymeric nanoparticles - Ahmad Jabbarzadeh
• Multifunctional polymer nanostructures - Markus Muellner
• Nano safety and sustainability - Wojciech Chrzanowski
• Nano-engineered reversible energy storage - Thomas Maschmeyer
• Nanoscale fluid flow at solid surfaces - Luming Shen
• Nanoscale photonic circuits - Benjamin Eggleton
• Nanotechnology for sustainable energy - Anita Ho-Baillie
• New insights into disease and drug targets - Georges Grau, Peter Lay, Nicholas Jonathan Cole King
• Quasielastic neutron scattering - Chris Ling
• Quantum control with trapped ions - Michael Biercuk
• Self-assembled protein nanocompartments - Yu Heng Lau
• Semiconducting nanowires - Rongkun Zheng
• Silicon photonics nanofabrication - Benjamin Eggleton
• Special wettability nanostructured surfaces - Chiara Neto
• Tailoring carbon nanomaterials - Yuan Chen

Sydney Nano Networks are created and co-led with faculties. They are aligned to faculty strategies and will form integrated large-scale research focus areas with the potential of achieving transformational research outcomes and global impact. The networks connect researchers from different faculties with each other and with end-users and partners to form clusters that together form the Network. 

Sydney NanoHealth Network

Chairs: Ben Eggleton (Sydney Nano), Mark Rees (Faculty of Medicine & Health)

Based on a pan-university scoping study of existing expertise in the field of nanoscience and technology for health application, the Sydney NanoHealth Network has been established comprising 6 clusters:

Nano Pharma

• Nicholas Hunt, Lecturer, Concord Clinical School
• Pegah Varamini, Lecturer, Sydney Pharmacy School

Nano-Bio-Engineering

• Yogambha Ramaswamy, Lecturer, School of Biomedical Engineering
• Steven Wise, Associate Professor, School of Medical Sciences

Computational Medicine

• Lamiae Azizi, Senior Lecturer, School of Mathematics
• Svetlana Postnova, Senior Lecturer, School of Physics

Sensors and Diagnostics

• David Martinez Martin, Senior Lecturer, School of Biomedical Engineering
• Corinne Caillaud, Associate Professor, Sydney School of Health Sciences

Lab/Organ-on-Chips

• Stuart Fraser, Associate Professor, School of Medical Sciences
• Stefano Palomba, Associate Professor, School of Physics

Nanoparticles for Biomedical Applications

• Anna Waterhouse, Senior Lecturer, School of Medical Sciences
• Wojciech Chrzanowski, Associate Professor, Sydney Pharmacy School