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Clinical utility of MS molecular phenotypes of MS

My group at the Centre for Immunology aims to translate immunogenetic findings from discovery to clinical practice. We have used genome wide association studies to identify genetic more...

Supervisor(s): Booth, David (Associate Professor)

Determining the functional significance of non-coding DNA variants in genes for complex traits involving gene-environmental interactions

To identify non-protein coding DNA changes in genes that interact with the environment using 2 models – sporadic amyotrophic lateral sclerosis for the vulnerability to environ more...

Supervisor(s): Yu, Bing (Associate Professor)

MS-risk genes and EBV or other virus infection

My group at the Centre for Immunology aims to translate immunogenetic findings from discovery to clinical practice. We have used genome wide association studies to identify genetic more...

Supervisor(s): Booth, David (Associate Professor)

Dysferlin and defective membrane repair in muscular dystrophy

We are studying a form of muscular dystrophy caused by deficiency of the protein dysferlin. Dysferlin patients have a primary defect in skeletal muscle membrane repair, and are unab more...

Supervisor(s): Cooper, Sandra (Dr)

Strengthening brittle bones

Osteogenesis imperfecta (OI) or "brittle bone disease" can be caused by a range of proteins involved with the bone matrix. Children with OI are prone to fracture, which can reduce m more...

Supervisor(s): Schindeler, Aaron (Associate Professor), Little, David (Professor), Munns, Craig (Associate Professor)

GENES AND CELL-CELL INTERACTIONS IN CANCER PROGRESSION..

Oncogenes, tumour suppressor genes and cell-cell interactions in cancer: which are important in driving tumour progression and invasion in squamous cell carcinomas? more...

Supervisor(s): Lyons, Guy (Associate Professor)

Biochemistry and cell biology of the cancer-associated enzyme telomerase

Telomerase is the enzyme responsible for lengthening the ends of chromosomes (telomeres), thereby allowing most cancer cells to divide indefinitely.  We are determining the mec more...

Supervisor(s): Bryan, Tracy (Associate Professor), Cohen, Scott (Dr)

REGULATION OF GROWTH FACTOR SIGNALLING IN THE EYE AND ITS IMPLICATIONS FOR NORMAL LENS BIOLOGY AND PATHOLOGY.

Growth factors play an essential role in regulating lens cell behaviour in the eye. Diverse intracellular signalling pathways work in concert or oppose each other to promote and reg more...

Supervisor(s): Lovicu, Frank J. (Professor)

Control of cell differentiation during mouse embryogenesis and stem cell development

The research will provide insights into how progenitor cells for embryonic tissues may be specified and determine the conditions that promote differentiation into germ layer derivat more...

Supervisor(s): Tam, Patrick (Professor)

A Novel Approach of Inhibiting Pancreatic Cancer Metastasis via Targeting Tumour Micro-Environment Induced Autophagy

Targeting autophagy and metastasis in pancreatic cancer via NDRG1 Pancreatic Cancer (PC) is highly metastatic with the highest mortality of all cancers (~93%). The pancreatic tu more...

Supervisor(s): Sahni, Sumit (Dr)