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Medicinal Chemistry and Biology - Development of Novel Anti-Tumour Agents for Cancer Treatment

This project is involved in the exciting development of novel drugs for the treatment of cancer and other conditions. more...

Supervisor(s): Richardson, Des (Professor)

Biology of Dipeptidyl Peptidase IV and related proteins

Research projects centre on mouse models of liver disease and obesity and on the delineation of inhibitors, substrates, biochemistry and in vivo expression and function of the Dipep more...

Supervisor(s): Gorrell, Mark (Associate Professor)

How invasive cancer cells negotiate the 3D tissue environment

My team uses cell biology approaches to discover the cellular machinery that allows deadly, invasive cancer cells to negotiate the surronding 3D environment. more...

Supervisor(s): O'Neill, Geraldine (Associate Professor)

Mechanisms of T cell migration and interactions in the tumor microenvironment

The project will use intravital two-photon microscopy to determine the molecules involved in interstitial T cell migration and the molecular mechanisms of T cell interactions with t more...

Supervisor(s): Weninger , Wolfgang (Professor)

GENES AND CELL-CELL INTERACTIONS IN CANCER PROGRESSION..

Oncogenes, tumour suppressor genes and cell-cell interactions in cancer: which are important in driving tumour progression and invasion in squamous cell carcinomas? more...

Supervisor(s): Lyons, Guy (Associate Professor)

The transformation of normal melanocytes into melanoma

This project investigates the role of the oncogenes Ras and Braf and the tumour suppressors p16INK4a, p14ARF, p53 and PTEN in the malignant transformation of melanocytes. more...

Supervisor(s): Kefford, Richard (Professor)

Targeting melanoma secretory pathways.

Cancer cells secrete a variety of factors that induce tumour growth, metastasis, angiogenesis, and alter the tumour stroma to create a more favourable microenviroment. This project more...

Supervisor(s): Weninger , Wolfgang (Professor), Beaumont, Kimberley (Dr)

An investigation into the mechanisms of immune evasion in metastatic melanoma patients treated with molecular or immune checkpoint inhibitors.

The aim of this project is to characterise the immune reaction and prevalence of immune inhibitory mechanisms present in metastatic melanoma patient tumours whilst on immune checkpo more...

Supervisor(s): Scolyer, Richard (Professor), Long, Georgina (Professor)

Role of Vitamin D and other compounds in protection of skin cells from UV

This study examines how vitamin D compounds protect skin from sun or UV-induced DNA and other damage. more...

Supervisor(s): Mason, Rebecca (Professor)

Cancer Stem Cells

Cancer stem cell research more...

Supervisor(s): Hebbard, Lionel (Dr)