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Unit of study_

BCMB3003: Biochemistry of Human Disease

Diseases are ultimately the result of an imbalance of cellular function. Causes for such dysfunction are diverse and include mutations of our DNA, altered gene expression and external stimuli such as infection. This unit will investigate how defects in key cell functions including gene expression, signalling, biomolecular interactions and metabolic processes lead to diseases. The molecular causes and biochemical processes that underlie cancer, aging and neurodegeneration will be used to illustrate the relationships between these processes and how our understanding of these commonalities is allowing us to solve complex health problems. Associations to other diseases will be integrated into the course to give a broader understanding of how key biochemical processes are linked to a wide range of disorders. In the practicals you will use experimental approaches to study cell proliferation and death, protein misfolding, the hallmarks of cancer and some neurodegenerative diseases. By the end of this unit you will have gained foundational skills and knowledge that will support further studies and careers in the life and medical sciences.

Code BCMB3003
Academic unit Life and Environmental Sciences Academic Operations
Credit points 6
12 credit points from (BCHM2X71 or BCHM2X72 or BCMB2X01 or BCMB2X02 or MEDS2003 or MBLG2X01) or [6 credit points from (BCHM2X71 or BCHM2X72 or BCMB2X01 or BCMB2X02 or MEDS2003 or MBLG2X01) and 6 credit points from (AMED3001 or BCHM3XXX or BCMB3XXX or BIOL2X29 or BMED2401 and BMED2405 or GEGE2X01 or MEDS2002 or PCOL2X21 or QBIO2001)] or 12 credit points from (BMED2401 and BMED2405)
BCMB3903 or (BCHM3X72 and BCHM3X82)
Assumed knowledge:
Protein chemistry and biochemistry concepts at 2000-level units

At the completion of this unit, you should be able to:

  • LO1. Describe the components involved in the cell cycle and predict how specific gene mutations will affect the cell cycle and cell proliferation.
  • LO2. Adapt experimental techniques to address a specific question and analyse aspects of the cell cycle and cell proliferation using biochemical assays.
  • LO3. Design an experimental plan to study aspects of cell proliferation and cell death, and conduct the experiment.
  • LO4. Explain the processes involved in protein folding and misfolding and evaluate experimental studies in that area.
  • LO5. Perform and evaluate a biochemical assays to determine protein concentrations in solutions using different approaches.
  • LO6. Evaluate and communicate experimental data by composing a scientific paper based on your own experimental results.
  • LO7. Critically evaluate experimental data.
  • LO8. Collaborate by working in a small team to solve a scientific problem.
  • LO9. Obtain and explain the difference between qualitative and quantitative measurements and data.
  • LO10. Judge validity of data and solve scientific calculations.