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Unit of study_
MCHM3901: From Molecules to Therapeutics (Advanced)
Major changes to the way we discover and develop new medicines have taken place in recent years. Sequencing of the human genome has revolutionised drug target identification and therapeutic design. Genomics approaches that combine molecular biology and intensive data analysis are key to the development of personalised and precision therapies. New methods in organic synthesis have accelerated how we explore chemical space, developments in nanotechnology are driving innovative drug delivery methods. In this unit you will explore how these new ideas and technologies transforming medicinal chemistry. You will learn and apply such techniques to the molecular-level understanding of diseases and the design of effective therapeutics. You will learn the procedures leading to drug registration and regulation. You will participate in enquiry-led practicals that reinforce the concepts of the unit and develop your skills in cutting-edge methods used in modern medicinal chemistry. By studying this unit you will build knowledge and skills that will enable you to play a role in creating therapeutics that will impact lives. You will learn and apply such techniques to the molecular-level understanding of diseases and the design of effective therapeutics. The advanced unit has the same overall concepts as the mainstream unit but the material is discussed in a manner that offers a greater level of challenge and academic rigour. Students enrolled in the advanced stream will participate in alternative components, which may vary from year to year.
| Code | MCHM3901 |
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| Academic unit | Department of Medical Sciences |
| Credit points | 6 |
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Prerequisites:
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A mark of 70 or above in each of [(PCOL2011 or PCOL2021 or MEDS2002) or (BMED2401 and BMED2402) or (BMED2401 and BMED2405) or in each unit of (12cp from BCMB2XXX)] AND a mark of 70 or above in [(CHEM2401 or CHEM2521 or CHEM2911 or CHEM2915 or CHEM2921 or CHEM2991)] |
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Corequisites:
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None |
| Prohibitions:
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MCHM3001 |
At the completion of this unit, you should be able to:
- LO1. demonstrate an understanding of major developments in modern drug discovery, ranging from analysis of bioinformatics through combinatorial synthetic methods and fragment-based screening, to formulation, preclinical development, delivery and registration.
- LO2. apply bioinformatics and in silico methods to drug target identification and drug optimisation
- LO3. propose and justify reasonable synthetic approaches towards small organic molecule drug candidates
- LO4. Understand and apply the principles of scientific measurement during a fragment-based screening project.
- LO5. find and analyse information and judge its reliability and significance when evaluating the efficacy of drug action.
- LO6. communicate scientific information appropriately, both orally and through written work
- LO7. engage in team and group work to assess the development, approval and registration of new drugs
- LO8. demonstrate a sense of responsibility, ethical behaviour, and independence as a learner and as a scientist.
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