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Unit of study_
PCOL3912: Drug Design and Development (Advanced)
2024 unit information
Do you want to be the designer of the next billion dollar drug? In this unit of study you will apply your foundational knowledge and skills in medicinal chemistry and pharmacology to understand the discovery, design and development of major drug classes. You will gain knowledge into what makes a good drug target and how to design a new drug from lead drug identification to target optimisation. Drugs targeting a wide variety of genes, proteins, enzymes and receptors are explored through practicals and tutorials on molecular modelling and structure-activity relationships. The course also extends to a section on the design of diverse pharmacological agents, including compounds for imaging by positron emission tomography (PET) and drug applications based on proteomic and genomic big data. You will be set special advanced assignments related to the material covered in core areas. These may also involve advanced practical work or detailed investigation of a theoretical problem. This unit of study is highly recommended for students interested in careers in drug discovery and development including pharmaceutical industry, government, and medical research pathways.
Unit details and rules
Managing faculty or University school:
Pharmacy
| Code | PCOL3912 |
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| Academic unit | Pharmacy |
| Credit points | 6 |
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Prerequisites:
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a mark of 70 or above in {(PCOL2011 or PCOL2021 or MEDS2002) or [BMED2401 and 6cp from (BMED2402 or BMED2405)] or 12cp from BCMB2XXX} |
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Corequisites:
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None |
| Prohibitions:
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PCOL3012 |
| Assumed knowledge:
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None |
At the completion of this unit, you should be able to:
- LO1. identify classes of pharmacologically important macromolecules as drug targets
- LO2. recognise the role that structure and molecular properties (e.g. pKa, log P, log D) play in intramolecular interactions and their importance in drug action and design
- LO3. explain principles underpinning the design of new drug molecules
- LO4. explain principles underpinning the design of new protein therapeutics
- LO5. understand the concept of a pharmacophore in drug-receptor interactions
- LO6. explain various research methods used in the process of drug discovery, formulation, and delivery, and explain and interpret the types of data obtained
- LO7. explain the different types of pharmaceutical dosage forms through which a drug molecule may be delivered
- LO8. demonstrate confidence in the use of computer programs for studying pharmacology and for writing pharmacology reports
- LO9. use the most relevant pharmacology and medicinal chemistry databases to locate specific papers, and to find relevant resources related to topics as allocated
Unit availability
This section lists the session, attendance modes and locations the unit is available in. There is a unit outline for each of the unit availabilities, which gives you information about the unit including assessment details and a schedule of weekly activities.
The outline is published 2 weeks before the first day of teaching. You can look at previous outlines for a guide to the details of a unit.
Modes of attendance (MoA)
This refers to the Mode of attendance (MoA) for the unit as it appears when you’re selecting your units in Sydney Student. Find more information about modes of attendance on our website.
