This unit examines the worldwide status and trends in child and adolescent allergic disease. It explores the determinants, clinical assessment, medical complications, management and prevention of these important public health problems. Our aim is to inspect the current clinical practice and principles that underlie the diagnosis and management of paediatric allergic disorders. There is a close integration of epidemiology, basic science and best available evidence in management that are revealed through clinically based scenarios. Important cutting edge and controversial concepts and treatments are explored.
At the completion of this unit, you should be able to:
LO1. Describe and discuss epidemiology and pathophysiology of allergic disorders in children
LO2. Describe and appraise the evidence for primary prevention strategies, controversies, novel treatments and determinants of outcome in allergic disorders
LO3. Describe and discuss the concepts relating to atopic march, IgE and non IgE mediated food allergy, atopic dermatitis and urticaria
LO4. Demonstrate a high-level ability to recognise, diagnose and manage complex chronic allergic children who present with multiple system involvement and allergic disorders which are resistant to standard treatments.
LO5. Describe and discuss the typical clinical presentation and clinical features of Allergic rhinitis and Insect allergy
LO6. Demonstrate ability to recognise, diagnose and manage allergic disorders including those with complex multiple system involvement and drug resistant scenarios
LO7. Demonstrate a high-level ability to understand the mechanism by which immunotherapy may work in allergic rhinitis and insect allergy
LO8. Review and recognise the components of the human innate immune system and adaptive immune response - cellular and humoral and their physiological roles
LO9. Explain the role and importance of pattern recognition receptors (PRR) and recognize immune defects in this pathway
LO10. Be able to understand and describe T lymphocyte subsets, their development and function in normal immune response and disease states
LO11. Understand the pathophysiological basis of SCID and apply this understanding to interpret newborn screening for SCID, clinical presentations with SCID and treatment principles
LO12. Be able to understand antibody diversity and explain B lymphocyte development and antibody production in normal immune response and disease states
LO13. Discriminate various examples of immune deficiencies associated with antibody deficiency
LO14. Develop an understanding of immunogenomics through examples of monogenic models of disease
LO15. Understand and describe the pathophysiologic mechnsisms for autoimmunity and autoinflammation
LO16. Integrate the understanding of pathophysiologic pathways in diseases of the immune system to recognise the use of selected biologic treatments
Unit availability
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